Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction

Kanji, Rahim, Gue, Ying X., Farag, Mohamed F., Spencer, Neil H., Mutch, Nicola J. and Gorog, Diana A. (2022) Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction. JACC: Basic to Translational Science, 7 (11). pp. 1069-1082. ISSN 2452-302X

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Hypofibrinolysis is a recently-recognized risk factor for recurrent cardiovascular events in patients with ST-segment elevation myocardial infarction (STEMI), but the mechanistic determinants of this are not well understood. In patients with STEMI, we show that the effectiveness of endogenous fibrinolysis in whole blood is determined in part by fibrinogen level, high sensitivity C-reactive protein, and shear-induced platelet reactivity, the latter directly related to the speed of thrombin generation. Our findings strengthen the evidence for the role of cellular components and bidirectional crosstalk between coagulatory and inflammatory pathways as determinants of hypofibrinolysis.

Item Type	Article
Additional information	© 2022 The Author(s). Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives CC BY-NC-ND licence, https://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords	fibrinolysis, myocardial infarction, platelet function, thrombosis, cardiology and cardiovascular medicine
Date Deposited	15 May 2025 14:55
Last Modified	31 May 2025 00:34

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