In vitro and in vivo TNFa synthesis modulation by methylguanidine, an uremic catabolyte

Autore, G., Marzocco, S., Sorrentino, R., Mirone, V. G., Baydoun, A. R. and Pinto, A. (1999) In vitro and in vivo TNFa synthesis modulation by methylguanidine, an uremic catabolyte. Life Sciences, 65 (11). ISSN 0024-3205
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We have investigated whether methylguanidine (MG), an uremic toxin, modulates the expression of the inducible nitric oxide synthase (iNOS) and nitric oxide (NO) release in vitro in LPS-induced J774 macrophages.

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