Inhibition of ornithine decarboxylase potentiates nitric oxide production in LPS-activated J774 cells

Baydoun, A. R. and Morgan, D. M. L. (1998) Inhibition of ornithine decarboxylase potentiates nitric oxide production in LPS-activated J774 cells. pp. 1511-1516. ISSN 0007-1188
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We have examined whether modulation of the polyamine biosynthetic pathway, through inhibition by α-difluoromethylornithine (DFMO) of the rate limiting enzyme, ornithine decarboxylase (ODC), modulates NO synthesis in J774 macrophages.

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