Cerebellar output controls generalized spike-and-wave discharge occurence

Kros, Lieke, Eelkman Rooda, Oscar, Spanke, Jochen, Alva, Parimala, van Dongen, Marijn, Karapatis, Athanasios, Tolner, Else, Strydis, Christos, Davey, N., Winkelman, Beerend, Negrello, Mario, Serdijn, Wouter, Steuber, Volker, van den Maagdenberg, Arn, De Zeeuw, Chris I. and Hoebeek, Freek E. (2015) Cerebellar output controls generalized spike-and-wave discharge occurence. Annals of Neurology, 77 (6). pp. 1027-1049. ISSN 1531-8249

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Disrupting thalamocortical activity patterns has proven to be a promising approach to stop generalized spike-and-wave discharges (GSWDs) characteristic of absence seizures. Here, we investigated to what extent modulation of neuronal firing in cerebellar nuclei (CN), which are anatomically in an advantageous position to disrupt cortical oscillations through their innervation of a wide variety of thalamic nuclei, is effective in controlling absence seizures

Item Type	Article
Additional information	© 2015 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (CC BY-NC-ND 4.0) which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Date Deposited	15 May 2025 12:52
Last Modified	31 May 2025 07:02