Tolevamer is not efficacious in the neutralization of cytotoxin in a human gut model of Clostridium difficile infection

Baines, Simon D., Freeman, Jane and Wilcox, M. H. (2009) Tolevamer is not efficacious in the neutralization of cytotoxin in a human gut model of Clostridium difficile infection. Antimicrobial Agents and Chemotherapy, 53 (5). pp. 2202-4. ISSN 1098-6596
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The efficacy of tolevamer, a nonantimicrobial styrene derivative toxin-binding agent, in treating simulated Clostridium difficile infection in an in vitro human gut model was investigated. Tolevamer reduced neither the duration nor magnitude of cytotoxin activity by C. difficile, reflecting poor efficacy observed in recent phase III clinical trials.
Item Type Article
Date Deposited 15 May 2025 12:33
Last Modified 30 May 2025 23:53

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